COVID-19: Connect with Your Dermatology Provider from the Comfort of Your Home. Due to the outbreak of COVID-19, it’s now possible to connect virtually for examinations, recommendations, along with having prescriptions filled to treat your acne. Contact your dermatology provider to find out if they offer virtual appointments.


No single topical acne treatment has been proven to be safe and effective in treating acne on the face, chest, shoulders, and back.1-3

No more shying away from life’s moments. TREATING ACNE BEYOND JUST YOUR FACE.

It was also proven effective on chest, shoulders, and back acne. AKLIEF® (trifarotene) Cream, 0.005% works by removing dead skin cells from the surface to help unclog pores, and help prevent new acne from forming. It also reduces the inflammation often experienced with pimples.


Target acne with your new secret weapon: trifarotene.

Precise & Selective
The active ingredient in AKLIEF Cream is trifarotene, an innovative retinoid that specifically targets the root cause of acne.

Treating From All Angles
AKLIEF Cream starts to work quickly and is proven to be just as effective in treating acne on the face as across the chest, shoulders, and back.



Watch a short video to learn how to use AKLIEF Cream correctly to help get the most from your treatment.


A simple daily routine.


1. CLEANSE the areas to be treated with a mild or soapless cleanser and pat dry.

2. APPLY a thin layer of AKLIEF Cream to the affected areas once a day in the evening. One pump for the face, two pumps for the chest, shoulders, and back.

3. MOISTURIZE as often as needed to help minimize skin dryness and irritation.

4. AVOID SUN by using sunscreen and wearing protective clothing.

Frequently asked questions:


Who can use AKLIEF Cream?

AKLIEF Cream is a prescription retinoid indicated for the topical treatment of acne vulgaris in patients 9 years of age and older.
You should apply AKLIEF Cream to the affected area once a day in the evening. If you have to be in sunlight, or are sensitive to sunlight, use a sunscreen with an SPF (sun protection factor) of 15 or more, and wear protective clothing and a wide-brimmed hat to cover the treated areas.
For your face, use 1 pump. For your upper back, shoulders, and chest, use 2 pumps. An additional pump may be used for your middle to lower back if needed.
If you can’t reach or don’t have anyone to help, applicators can be used to help you apply the cream where it’s needed.
Don’t double the dose to make up for the forgotten one. Just continue the next day with the same amount of product. Try and keep using it as your doctor instructed to get the most out of your treatment.
Avoid contact with your eyes, lips, mouth, the corners of your nose, and vagina.
Minimize exposure to sunlight. You should avoid using sunlamps, tanning beds, and ultraviolet light during treatment with AKLIEF Cream. If you have to be in sunlight or are sensitive to sunlight, use a sunscreen with an SPF (sun protection factor) of 15 or more, and wear protective clothing and a wide-brimmed hat to cover the treated areas. Avoid using AKLIEF Cream on skin areas with cuts, abrasions, eczema, or on sunburned skin. Avoid using skin products that may dry or irritate your skin, such as:
  • medicated or abrasive soaps and cleansers
  • soaps, cleansers, and cosmetics that have strong skin drying effects
  • products that contain high amounts of alcohol
Avoid the use of “waxing” as a hair removal method on skin treated with AKLIEF Cream.
You may notice your acne improving as early as 2 weeks. In clinical trials, patients were asked to use AKLIEF Cream for 12 weeks.3 You should continue with your treatment as your doctor directed.
There’s a chance your acne could come back when you stop AKLIEF Cream. That doesn’t mean the treatment didn’t work properly, but pores can become clogged again, causing acne to reappear. Follow your doctor’s instructions on your treatment using AKLIEF Cream.
Keeping your skin healthy and sticking with your acne-friendly skin care routine may help. Here are some useful tips:
  • Clean your skin gently, with a mild non-abrasive soap, at least once a day
  • Use skin care products that won’t clog your pores. Look for “non-comedogenic” or “oil-free” labels on the packaging
  • Wash your skin after exercise
  • Wear loose-fitting clothing
Store AKLIEF Cream at room temperature, 68° to 77° F (20° to 25°C).
  • Keep AKLIEF Cream away from heat
  • If you receive a sample tube of AKLIEF Cream from your doctor, keep the tube tightly closed
Keep AKLIEF Cream and all medicines out of the reach of children.
The most common side effects of AKLIEF Cream include: application site irritation, itching, and sunburn.

AKLIEF Cream may cause serious side effects, including: Local skin irritation. Local skin reactions are common with AKLIEF Cream, are most likely to happen during the first 4 weeks of treatment and may decrease with continued use of AKLIEF Cream. Signs and symptoms of local skin reactions include:
  • redness
  • scaling
  • dryness
  • stinging or burning
To help reduce your risk of developing these local skin reactions, when you begin treatment with AKLIEF Cream, you should begin applying a moisturizer on your skin as often as needed.

Tell your healthcare provider if you develop symptoms of a local skin reaction. Your doctor may tell you to use AKLIEF Cream less often, or to temporarily, or permanently stop your treatment with AKLIEF Cream.

These are not all the possible side effects of AKLIEF Cream. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA 1088.

You may also report side effects to GALDERMA LABORATORIES, L.P. at 1-866-735-4127.

References: 1. AKLIEF Press Release. Federal Drug Administration approval 2019. 2. AKLIEF® (trifarotene) Cream 0.005% [Prescribing Information]. Ft Worth, TX: Galderma Laboratories, L.P.; October 2019. 3. Tan J, Thiboutot D, Popp G, et al. Randomized phase 3 evaluation of trifarotene 50 µg/g cream treatment of moderate facial and truncal acne. J Am Acad Dermatol. 2019;80(6):1691-1699.


Indication: AKLIEF® (trifarotene) Cream, 0.005% is a retinoid indicated for the topical treatment of acne vulgaris in patients 9 years of age and older. Adverse Events: The most common adverse reactions (incidence ≥ 1%) in patients treated with AKLIEF Cream were application site irritation, application site pruritus (itching), and sunburn. Warnings/Precautions: Patients using AKLIEF Cream may experience erythema, scaling, dryness, and stinging/burning. Use a moisturizer from the initiation of treatment, and, if appropriate, depending upon the severity of these adverse reactions, reduce the frequency of application of AKLIEF Cream, suspend or discontinue use. Avoid application of AKLIEF Cream to cuts, abrasions or eczematous or sunburned skin. Use of “waxing” as a depilatory method should be avoided on skin treated with AKLIEF Cream. Minimize exposure to sunlight and sunlamps. Use sunscreen and protective clothing over treated areas when exposure cannot be avoided.


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.

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